1. Presented by Eric A. Gehrie, MD and prepared by Lorraine N. Blagg, MA, MLS(ASCP)SBB

Clinical Vignette

The patient was started on steroids, IVIG, and erythropoietin at the outside hospital and experienced a drop in hemoglobin to 3.5 g/dl. The patient was subsequently transfused with a RBC unit that was 3+ incompatible, and began to experience chills after only 10 ml of the blood product had been administered. The transfusion was stopped and patient was transferred to your hospital. Upon arrival, the patient had a hemoglobin of 2.5 g/dl, jaundice, and dark urine.

Question:
What would be the best recommendation for this patient given their current clinical presentation?