Case 143

1. Presented by Kevin Toomer, MD, PhD and reviewed by Lorraine N. Blagg, MA, MLS(ASCP)CMSBB

A young adult patient with sickle cell disease is admitted for management of intractable pain from vaso-occlusive crisis. Of note, they underwent red cell exchange transfusion at an outside facility several days prior to presentation. Initial type and screen had a negative antibody detection test for RBC alloantibodies. The patient had a notable decrease in hemoglobin over their hospital stay. A direct antiglobulin test (DAT) was performed.


Elution testing was performed, and an anti-V (RH10) alloantibody was identified in the eluate. Which of the following statements regarding this alloantibody is correct?