Transfusion Medicine Case 129 May 3, 2023 pathadmin 2,698 Comments 1. Prepared by Chen Lossos, MD and reviewed by Liz Crowe, MD and Lorraine N. Blagg, MA, MLS(ASCP)SBBAn elderly patient with high grade diffuse large B-cell lymphoma (DLBCL) is enrolled in a phase II trial of Rituximab and HU5F9-G4, an IgG4 antibody targeting CD47, after failing front-line rituximab, cyclophosphamide, hydroxydaunorubicin hydocholoride, oncovin, and prednisone (R-CHOP) and rituximab, ifosfamide, carboplatin, and etoposide (R-ICE) therapies. About a week after initiating treatment, they were transfused two crossmatched RBC units for a hemoglobin of 5.3 g/dl (7.1 g/dl pre-treatment). During transfusion of the second unit, the patient developed hives and urticaria, at which point the transfusion was stopped and a transfusion reaction work-up was sent. The transfusion work-up demonstrated no errors during the clerical check and there was no hemolysis in the post transfusion plasma. The ABO/Rh typing providing the following results.A literature search reveals that reverse-type ABO discrepancies have been reported with anti-CD47 therapy.In addition to the above, discrepancies in what other routine blood bank testing have been reported with treatment with anti-CD47 antibodies?A. Antibody screen and crossmatchB. Antigen typingC. DATD. All of the above Loading...