1. Presented by Parvez Lokhandwala MD, PhD and prepared by Jackie Birkness, MD & Kayla Erculiani BS

Clinical Vignette

An elderly patient with anemia related to cancer treatment is found to have blood type A+ with a negative antibody screen. The patient subsequently receives multiple red blood cell transfusions and develops a positive antibody screen with anti-Kp^a and anti-Le^a. A few months later, the patient has another positive antibody screen. In addition to the previously identified anti-Kp^a and anti-Le^a, a new antibody to a high frequency antigen is identified. An antibody identification panel and red blood cell genotype are performed and the results are shown below. A direct antiglobulin test is negative.

Antibody Identification Panel



Genotype



Question:
How do you interpret these results?