Transfusion Medicine Case 9 May 3, 2023 pathadmin 13 Comments 1. Presented by Parvez Lokhandwala MD, PhD and prepared by Jackie Birkness, MD & Kayla Erculiani BSClinical VignetteAn elderly patient with anemia related to cancer treatment is found to have blood type A+ with a negative antibody screen. The patient subsequently receives multiple red blood cell transfusions and develops a positive antibody screen with anti-Kpa and anti-Lea. A few months later, the patient has another positive antibody screen. In addition to the previously identified anti-Kpa and anti-Lea, a new antibody to a high frequency antigen is identified. An antibody identification panel and red blood cell genotype are performed and the results are shown below. A direct antiglobulin test is negative.Antibody Identification PanelGenotypeQuestion:How do you interpret these results? The patient has an anti-e autoantibody.The patient has an anti-e alloantibody, and may have an e antigen variant (partial e).It is not possible for a patient with e antigen to form anti-e, so the results are erroneous. Loading...
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